The Src pathway as a therapeutic strategy

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow et al. · Journal of Biological Chemistry · 1996 · 1.9K citations · Full text

Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor

Neil P. Shah, Chris Tran, Francis Y. Lee et al. · Science · 2004 · 1.8K citations

Imatinib Resistance, Imatinib-resistant Bcr-abl Mutants, Chronic Myeloid Leukemia +14

SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

Robert A. Blake, Martin A. Broome, Xiangdong Liu et al. · Molecular and Cellular Biology · 2000 · 583 citations · Full text

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Jennifer M. Golas, Kim Arndt, Carlo Etienne et al. · PubMed · 2003 · 414 citations

K562 Xenografts, Mixed-phenotype Acute Leukemia, Apoptosis +18

Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer

Matthew P. Goetz, David O. Toft, Joel M. Reid et al. · Journal of Clinical Oncology · 2005 · 334 citations · Full text