Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Richard S. Burns, Chuang C. Chiueh, Sanford P. Markey et al. · Proceedings of the National Academy of Sciences · 1983 · 2.1K citations · Full text

Medicine, Neuroscience, Pharmacology +17

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony J. Trevor, Neal Castagnoli · Biochemical and Biophysical Research Communications · 1984 · 1.1K citations

Life Sciences, Neuroscience, Pharmacology +14

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

Richard E. Heikkila, Lawrence Manzino, Felicitas S. Cabbat et al. · Nature · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +14

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

Sanford P. Markey, Jan N. Johannessen, Chuang C. Chiueh et al. · Nature · 1984 · 780 citations

Medicine, Neuroscience, Pharmacology +11

Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications

Robert M. Sapolsky, William A. Pulsinelli · Science · 1985 · 679 citations

Medicine, Neuroscience, Pharmacology +17