Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas

Inactivation of the DNA-Repair Gene<i>MGMT</i>and the Clinical Response of Gliomas to Alkylating Agents

Manel Esteller, Jesús García‐Foncillas, Esther Andion et al. · New England Journal of Medicine · 2000 · 2.2K citations · Full text

Medicine, Molecular Biology, Oncology +17

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

H. S. Friedman, R E McLendon, Tracy Kerby et al. · Journal of Clinical Oncology · 1998 · 422 citations · Full text

Medicine, Oncology, Pharmacology +17

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

Kurt A. Jaeckle, Harmon J. Eyre, Jeannette J. Townsend et al. · Journal of Clinical Oncology · 1998 · 297 citations

Medicine, Oncology, Radiation Oncology +16

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.

Michael Belanich, Monica Pastor, Terri Randall et al. · PubMed · 1996 · 246 citations

Medicine, Oncology, Pharmacology +17

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -&gt; A:T mutations of the TP53 tumor suppressor gene

Mitsutoshi Nakamura · Carcinogenesis · 2001 · 246 citations · Full text

Medicine, Molecular Biology, Oncology +17