Concepedia

Publication | Closed Access

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

DOI

418

Citations

0

References

1998

Year

H. S. Friedman, R E McLendon, Tracy Kerby, Margaret Dugan, Sandra H. Bigner, A J Henry, David M. Ashley, Jacob Krischer, Simon C. Lovell, Karima Rasheed,
Journal of Clinical Oncology

Abstract

These results suggest that Temodal has activity against newly diagnosed GBM and AA and warrants continued evaluation of this agent. Furthermore, pretherapy analysis of tumor DNA mismatch repair and, particularly, AGT protein expression may identify patients in whom tumors are resistant to Temodal.