Rho GTPases Control Ciliary Epithelium Cells Proliferation and Progenitor Profile Induction In Vivo

Abstract

This study reports that Rho GTPase modulation (activation and inactivation) controls the expression of retinal progenitor genes and proliferation, respectively, in the adult ciliary epithelial progenitor/stem cells of rodent eyes. The modulation of these two different mechanisms (proliferation and reprogramming) may provide a potential new approach in retinal repair.