Correlation of Functional and Ultrastructural Abnormalities of Mitochondria in Mouse Heart Carrying a Pathogenic Mutant mtDNA with a 4696-bp Deletion

NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB)

Arnold M. Seligman, Morris J. Karnovsky, Hannah L. Wasserkrug et al. · The Journal of Cell Biology · 1968 · 891 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

J Hayashi, Shigeo Ohta, Azusa Kikuchi et al. · Proceedings of the National Academy of Sciences · 1991 · 554 citations

Life Sciences, Genetics, Molecular Biology +17

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

Kazuto Nakada, Kimiko Inoue, Tomoko Ono et al. · Nature Medicine · 2001 · 422 citations

Life Sciences, Genetics, Molecular Genetics +12

Defects in Mitochondrial Protein Synthesis and Respiratory Chain Activity Segregate with the tRNA^Leu(UUR) Mutation Associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes

Michael P. King, Yasutoshi Koga, Mercy M. Davidson et al. · Molecular and Cellular Biology · 1992 · 421 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

Tomoko Ono, Kotoyo Isobe, Kazuto Nakada et al. · Nature Genetics · 2001 · 411 citations

Life Sciences, Cell Biology, Molecular Biology +8