Concepedia

Modulation of cyclophosphamide activity by O ? 6 -alkylguanine-DNA alkyltransferase

Stewart P. Johnson, Natalia A. Loktionova, M. Eileen Dolan, Paul Modrich, Robert F. Struck, Thomas P. Brent, Susan M. Ludeman, Steve Keir, Qing Dong, O. Michael Colvin,

Cancer Chemotherapy and Pharmacology · 1999 · 55 citations · 11 references

DOI

Concepts

References

11

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

Anthony E. Pegg · PubMed · 1990 · 738 citations

, , +14

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

M. Eileen Dolan, Robert C. Moschel, Anthony E. Pegg · Proceedings of the National Academy of Sciences · 1990 · 461 citations

, , +9

Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde.

Fung Lung Chung, Ruth Young, Stephen S. Hecht · PubMed · 1984 · 300 citations

, , +15

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.

Henry S. Friedman, O. Michael Colvin, Stephen X. Skapek et al. · PubMed · 1988 · 132 citations

, , +11

Enhancement of Nitrosourea Activity in Medulloblastoma and Glioblastoma Multiforme

Henry S. Friedman, M. Eileen Dolan, Robert C. Moschel et al. · JNCI Journal of the National Cancer Institute · 1992 · 103 citations

, , +12