Concepedia

Thomas P. Brent

TP

Statistics

Publications

78

Citations

4.2K

H-Index

39

Active since

1965

Affiliations

St. Jude Children's Research Hospital(Current)

McGill University

University of Tennessee at Knoxville

Duke Medical Center

Oak Ridge National Laboratory

Thomas P. Brent is an author at St. Jude Children's Research Hospital specializing in molecular biology, natural sciences, and medicine.

Top concepts

Publications per year

1965–2005

78

Publications

78

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

Xilin C. Qian, Thomas P. Brent · PubMed · 1997 · 215 citations

, , +19

Variations in Phosphokinase Activities During the Cell Cycle in Synchronous Populations of HeLa Cells

Thomas P. Brent, J. A. V. Butler, A.R. Crathorn · Nature · 1965 · 163 citations

, , +10

Characterization of the promoter region of the human O<sup>6</sup>-methylguanine-DNA methyltransferase gene

Linda C. Harris, Philip M. Potter, Keizo Tano et al. · Nucleic Acids Research · 1991 · 140 citations · Full text

, , +16

Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.

Peter J. Houghton, Clinton F. Stewart, Pamela J. Cheshire et al. · PubMed · 2000 · 138 citations

, , +21

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

Thomas P. Brent, Peter J. Houghton, Janet A. Houghton · Proceedings of the National Academy of Sciences · 1985 · 135 citations · Full text

, , +18

1–5 of 78