Thomas P. Brent

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

Xilin C. Qian, Thomas P. Brent · PubMed · 1997 · 215 citations

Medicine, Genetics, Oncology +16

Variations in Phosphokinase Activities During the Cell Cycle in Synchronous Populations of HeLa Cells

Thomas P. Brent, J. A. V. Butler, A.R. Crathorn · Nature · 1965 · 163 citations

Life Sciences, Biochemistry, Cell Biology +14

Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene

Linda C. Harris, Philip M. Potter, Keizo Tano et al. · Nucleic Acids Research · 1991 · 140 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.

Peter J. Houghton, Clinton F. Stewart, Pamela J. Cheshire et al. · PubMed · 2000 · 138 citations

Medicine, Oncology, Pharmacology +17

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

Thomas P. Brent, Peter J. Houghton, Janet A. Houghton · Proceedings of the National Academy of Sciences · 1985 · 135 citations · Full text

Medicine, Oncology, Pharmacology +9