Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Life Sciences, Genetics, Immunology +13

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

Freddy Radtke, Anne E. Wilson, Gerlinde Stark et al. · Immunity · 1999 · 1.4K citations · Full text

Life Sciences, Genetics, Immunology +14

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

Peggy P. Lee, David Fitzpatrick, Caroline Beard et al. · Immunity · 2001 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

Peter Mombaerts, Alan R. Clarke, Michael A. Rudnicki et al. · Nature · 1992 · 1.1K citations

Life Sciences, Genetics, Immunology +16