Concepedia

Use of simulated intestinal fluid for Caco-2 permeability assay of lipophilic drugs

Lina Fossati, Rachel Dechaume, Emmanuel Hardillier, Delphine Chevillon, Colette Prévost, Sébastien Bolze, Nathalie Maubon

International Journal of Pharmaceutics · 2008 · 85 citations · 30 references

DOI

Concepts

References

30

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 2.2K citations

, , +14

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

, , +16

Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture

M. Pinto · HAL (Le Centre pour la Communication Scientifique Directe) · 1983 · 1.8K citations · Full text

, , +7

Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Manfred Kansy, Frank Senner, Klaus Gubernator · Journal of Medicinal Chemistry · 1998 · 1.3K citations

, , +16