Concepedia

Solute Crystallization in Mannitol–Glycine Systems—Implications on Protein Stabilization in Freeze‐Dried Formulations

Abira Pyne, Koustuv Chatterjee, Raj Suryanarayanan

Journal of Pharmaceutical Sciences · 2003 · 73 citations · 21 references

DOI

Concepts

References

21

Methods of enzymatic analysis

Food and Cosmetics Toxicology · 1966 · 4.3K citations

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An infrared spectroscopic study of the interactions of carbohydrates with dried proteins

John F. Carpenter, John H. Crowe · Biochemistry · 1989 · 753 citations

, , +15

Are freezing and dehydration similar stress vectors? A comparison of modes of interaction of stabilizing solutes with biomolecules

John H. Crowe, John F. Carpenter, Lois M. Crowe et al. · Cryobiology · 1990 · 462 citations

, , +11

The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

Michael J. Pikal, Karen M. Dellerman, R.M. Riggin · Pharmaceutical Research · 1991 · 273 citations

, , +14

The Physical State of Mannitol after Freeze-Drying: Effects of Mannitol Concentration, Freezing Rate, and a Noncrystallizing Cosolute

Alexandra I. Kim, Michael J. Akers, Steven L. Nail · Journal of Pharmaceutical Sciences · 1998 · 270 citations

, , +14