Concepedia

β1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension

J LIU, Zhaoqian Liu, Bin Yu, Fan Xu, Wuning Mo, G ZHOU, Yi Liu, Qiuxia Li, Hou‐De Zhou

Clinical Pharmacology & Therapeutics · 2006 · 141 citations · 21 references

DOI

Abstract

beta(1)-Adrenergic receptor polymorphism was associated with different blood pressure responses to metoprolol therapy in patients with essential hypertension. 49Ser389Arg/49Ser389Arg and 49Ser389Arg/49Gly389Arg patients were good responders to metoprolol therapy; 49Ser389Arg/49Ser389Arg patients had a larger systolic blood pressure reduction than 49Ser389Arg/49Gly389Arg patients did. 49Ser389Gly/49Gly389Arg and 49Ser389Gly/49Ser389Gly patients were nonresponders to metoprolol antihypertensive therapy.

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