Concepedia

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

Philip J. Webber, Archer D. Smith, Saurabh Sen, Matthew B. Renfrow, James A. Mobley, Andrew B. West

Journal of Molecular Biology · 2011 · 127 citations · 37 references

DOI

Concepts

References

37

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Alexander Zimprich, Saskia Biskup, Petra Leitner et al. · Neuron · 2004 · 3.1K citations · Full text

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Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Coro Paisán-Ruı́z, Shushant Jain, E. Whitney Evans et al. · Neuron · 2004 · 2.4K citations · Full text

, , +14

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Andrew B. West, Darren J. Moore, Saskia Biskup et al. · Proceedings of the National Academy of Sciences · 2005 · 1.2K citations · Full text

, , +16

Activation of Raf as a Result of Recruitment to the Plasma Membrane

David Stokoe, Susan G. Macdonald, Karen A. Cadwallader et al. · Science · 1994 · 985 citations

, , +15

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith, Zhong Pei, Haibing Jiang et al. · Nature Neuroscience · 2006 · 623 citations

, , +16