Spectroscopic Determination of Acid Dissociation Constants of Some Biologically Active 6-Phenyl-4,5-dihydro-3(2<i>H</i>)-pyridazinone Derivatives

Abstract

The acid dissociation constants, p K a, of twelve biologically active 6-phenyl-4,5-dihydro-3(2 H )-pyridazinone derivatives were determined using spectroscopic techniques. Elucidation of the structure−reactivity relationships was attempted from structural considerations based on the acid dissociation constants.