Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma

The Clonal Evolution of Tumor Cell Populations

Peter C. Nowell̀ · Science · 1976 · 6.5K citations

Medicine, Genetics, Oncology +17

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

Life Sciences, Cell Biology, Molecular Biology +14

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Medicine, Molecular Biology, Oncology +10

Thymocyte apoptosis induced by p53-dependent and independent pathways

Alan R. Clarke, Colin A. Purdie, David J. Harrison et al. · Nature · 1993 · 2.3K citations

Life Sciences, Cell Biology, Molecular Genetics +14