Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

A. De Léan, Jeffrey M. Stadel, Robert J. Lefkowitz · Journal of Biological Chemistry · 1980 · 1.6K citations · Full text

Medicine, Biochemistry, Pharmacology +17

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Philippe Samama, Susanna Cotecchia, Tommaso Costa et al. · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

A Quantitative Analysis of Beta-Adrenergic Receptor Interactions: Resolution of High and Low Affinity States of the Receptor by Computer Modeling of Ligand Binding Data

Richard S. Kent, Robert J. Lefkowitz · Molecular Pharmacology · 1980 · 555 citations

Medicine, Pharmacology, Biomolecular Modeling +16

The two-state model of receptor activation

Paul Leff · Trends in Pharmacological Sciences · 1995 · 505 citations

Life Sciences, Biochemistry, Molecular Biology +14