Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science · 1993 · 9.5K citations

Life Sciences, Genetics, Neurology +17

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

Joe Z. Tsien, Dong Feng Chen, David J. Gerber et al. · Cell · 1996 · 1.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ekaterina Rogaeva, Yan Meng, Joseph H. Lee et al. · Nature Genetics · 2007 · 1.2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo, Brad Bolon, Steve Kahn et al. · Nature Neuroscience · 2001 · 994 citations

Life Sciences, Genetics, Neuroscience +16