Cigarette smoking: profiles of throm☐ane- and prostacyclin-derived products in human urine

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Mortality in relation to smoking: 20 years' observations on male British doctors.

Richard Doll, Richard Peto · BMJ · 1976 · 1.3K citations · Full text

Public Health, Cardiology, Aging +15

St. Luke's Hostel

F. d. H. Hall · BMJ · 1895 · 606 citations

Increased Prostacyclin Biosynthesis in Patients with Severe Atherosclerosis and Platelet Activation

Garret A. FitzGerald, Bruce Smith, Anders Kirstein Pedersen et al. · New England Journal of Medicine · 1984 · 499 citations

Medicine, Biochemistry, Pharmacology +12

Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes.

Jacek Nowak, John Murray, John A. Oates et al. · Circulation · 1987 · 385 citations · Full text

Medicine, Geriatric Medicine, Surgery +14