Concepedia

Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists

Rieko Takano, Masao Yoshida, Masahiro Inoue, Takeshi Honda, Ryutaro Nakashima, Koji Matsumoto, Tatsuya Yano, Tsuneaki Ogata, Nobuaki Watanabe, Narihiro Toda

Bioorganic & Medicinal Chemistry Letters · 2014 · 22 citations · 32 references

DOIFull text

Open access

Concepts

References

32

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

, , +8

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Akira Hirasawa, Keiko Tsumaya, Takeo Awaji et al. · Nature Medicine · 2004 · 1.5K citations

, , +13

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

, , +16

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

Jun‐ichi Miyazaki, Kimi Araki, Eiji Yamato et al. · Endocrinology · 1990 · 1.3K citations

, , +15

The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

Celia P. Briscoe, Mohammad Tadayyon, John L. Andrews et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

, , +17