Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

David W. Fry, Alan J. Kraker, Amy McMichael et al. · Science · 1994 · 802 citations

Life Sciences, Oncology, Pharmacology +15

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

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Pharmacy, Medicinal Chemistry, Pharmacology +17

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Congxin Liang et al. · Journal of Medicinal Chemistry · 1999 · 272 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

Laurent Hennequin, Andrew P. Thomas, Craig Johnstone et al. · Journal of Medicinal Chemistry · 1999 · 236 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of Substituted 3-[(4,5,6,7-Tetrahydro-1<i>H</i>-indol-2-yl)methylene]- 1,3-dihydroindol-2-ones as Growth Factor Receptor Inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Congxing Liang et al. · Journal of Medicinal Chemistry · 2000 · 112 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17