SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

Alexander Laird, Peter Vajkoczy, Laura K. Shawver, +17

PubMed

PathologyCancer BiologyTumor BiologyAngiogenesisReceptor Tyrosine Kinase +21

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Congxin Liang, +7

Journal of Medicinal Chemistry

Tyrosine KinaseImmunologyPharmacotherapyPharmaceutical ChemistryMedicinal Chemistry +14

Ab initio studies of electron transfer: pathway analysis of effective transfer integrals

Congxin Liang, Marshall D. Newton

The Journal of Physical Chemistry

EngineeringProton-coupled Electron TransferAltmetric Attention ScoreExcitation Energy TransferBibliometrics +20

The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants

Sylvie Berthou, Daniel M. Aebersold, Laura S. Schmidt, +11

Oncogene

Signal TransductionSignaling PathwayG Protein-coupled ReceptorReceptor Tyrosine KinaseReceptor (Biochemistry) +6

Ab initio studies of electron transfer. 2. Pathway analysis for homologous organic spacers

Congxin Liang, Marshall D. Newton

The Journal of Physical Chemistry

EngineeringProton-coupled Electron TransferAltmetric Attention ScoreBibliometricsOrganic Chemistry +17

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

Isabelle Tanjoni, Colin Walsh, Sean Uryu, +11

Cancer Biology & Therapy

A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.

Mary Ellen Lane, Bo Yu, Audie Rice, +7

PubMed

Chemoprevention StrategyApoptosisCell DeathCell CycleCancer Biology +20

Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.

Xueyan Wang, Phuong Le, Congxin Liang, +12

PubMed

PathologySelective InhibitorsTumor BiologyOncologyMet Expression +14

Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.

Geoffrey W. Krystal, Sittisak Honsawek, David Kiewlich, +5

PubMed

Tumor BiologyOncologyChemoprevention StrategyKit ActivationKit Kinase +13

Group IV double bonds: shape deformation and substituent effects

Congxin Liang, Leland C. Allen

Journal of the American Chemical Society

EngineeringAltmetric Attention ScoreBibliometricsOrganic ChemistryChemistry +14