Novel Colloidal Materials for High‐Throughput Screening Applications in Drug Discovery and Genomics

Abstract

Tracking the reaction history is the means of choice to identify bioactive compounds in large combinatorial libraries. The authors show two approaches for synthesis on silica beads: (a) addition of a “reporter dye tag” during each synthesis step, which attaches itself to the bead by colloidal forces and (b) encapsulating arrays of fluorescent dyes into the beads to encode them uniquely, for recognition with a flow cytometer after each reaction step.