Biodistribution of polymer hydrogel capsules for the delivery of therapeutics

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

Hiroya Hashizume, Shunichi Morikawa, John W. McLean et al. · American Journal Of Pathology · 2000 · 1.7K citations · Full text

Medicine, Cell Biology, Oncology +10

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

Carlee E. Ashley, Eric C. Carnes, Genevieve K Phillips et al. · Nature Materials · 2011 · 1K citations · Full text

Pharmacy, Oncology, Pharmaceutics +17

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.

P. Vasey, Stan B. Kaye, Rachel Morrison et al. · PubMed · 1999 · 691 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Dynamic PolyConjugates for targeted <i>in vivo</i> delivery of siRNA to hepatocytes

David B. Rozema, David L. Lewis, Darren H. Wakefield et al. · Proceedings of the National Academy of Sciences · 2007 · 679 citations · Full text

Pharmacy, Molecular Biology, Pharmaceutics +17