Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Medicine, Pharmacology, Psychiatry +17

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Cristiano Chiamulera, Mark P. Epping-Jordan, Alessandro Zocchi et al. · Nature Neuroscience · 2001 · 549 citations

Life Sciences, Neurobiology, Neuroscience +14

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5

Zhengping Jia, Youming Lu, Jeff Henderson et al. · Learning & Memory · 1998 · 233 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17