Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists

Direct synthesis of Z-unsaturated esters. A useful modification of the horner-emmons olefination.

W. Clark Still, Cesare Gennari · Tetrahedron Letters · 1983 · 1K citations

Natural Sciences, Chemistry, Organic Chemistry +2

Structural Optimization Affording 2-(<i>R</i>)-(1-(<i>R</i>)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(<i>S</i>)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss et al. · Journal of Medicinal Chemistry · 1998 · 205 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Lithium-Initiated Imide Formation. A Simple Method for N-Acylation of 2-Oxazolidinones and Bornane-2,10-Sultam

Guo‐Jie Ho, David J. Mathre · The Journal of Organic Chemistry · 1995 · 151 citations

Natural Sciences, Chemistry, Medicinal Chemistry +5

In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists

N.M.J. Rupniak, F.D. Tattersall, Angela Williams et al. · European Journal of Pharmacology · 1997 · 117 citations

Medicine, Pharmacology, Pharmacotherapy +4

Neurokinin-1 (NK-1) Receptor Is Required in Antigen-Induced Cystitis

Ricardo Saban, Marcia R. Saban, Ngoc-Bich Nguyen et al. · American Journal Of Pathology · 2000 · 76 citations · Full text

Life Sciences, Immunology, Pathology +7