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Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β
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1999
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BiosynthesisBioorganic ChemistryBiochemistryBioassay-guided FractionationNatural SciencesDna Polymerase βPhytochemistryMolecular BiologyNatural Product BiosynthesisNew Diterpenoid-substituted QuinolChemical BiologyEnzymatic ModificationHigher Terrestrial PlantChrysochlamic Acid
Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 µM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl m-methylhydroquinone occurring in a higher terrestrial plant.