Concepedia

Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target

Ami V. Patel, David Eaves, Walter J. Jessen, Tilat A. Rizvi, Jeffrey Ecsedy, Mark G. Qian, Bruce J. Aronow, John P. Perentesis, Eduard Serra, Timothy P. Cripe,

Clinical Cancer Research · 2012 · 64 citations · 47 references

DOIFull text

Open access

Abstract

Integrative cross-species transcriptome analyses combined with preclinical testing has provided an effective method for identifying candidates for molecular-targeted therapeutics. Blocking Aurora kinases may be a viable treatment platform for MPNST.

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