Quantitative analysis of mixtures of drug delivery system components by Raman microscopy

Abstract

Abstract A series of two‐component powders and tableted mixtures of corn starch and lactose‐monohydrate were prepared and studied using the fiber optic sensor of a LabRam dispersion Raman microscope in order to establish a convenient method for quantitative determination of their concentration based on Raman spectra. The intensities of certain characteristic peaks of the components were used for calculating the calibration curve. Linear calibration curves were found in the concentration range of 10–80% with correlation coefficients of 0.9979–0.9996 for powders and tablets. Chemical mapping of the tablets was also carried out, thus allowing determination of the distribution of the components. Copyright © 2003 John Wiley & Sons, Ltd.