Publication | Closed Access
Total Synthesis of the Ethyl Ester of the Major Urinary Metabolite of Prostaglandin E<sub>2</sub>
28
Citations
13
References
2002
Year
Bioorganic ChemistryEthyl EsterSecondary MetaboliteOrganic ChemistryPharmaceutical ChemistryMedicinal ChemistryBiosynthesisKinetic OpeningNatural Product BiosynthesisSteroid MetabolismProstaglandin EBiochemistryMajor Urinary MetaboliteTotal SynthesisMetabolomicsPharmacologyNatural Product SynthesisPrimary MetaboliteEnantioselective SynthesisNatural SciencesMedicine
The preparation of the ethyl ester of the major urinary metabolite of prostaglandin E(2) 3 is described. The key step is the kinetic opening of the TBS-protected bicyclic ketone 7 with thiophenol.
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