Grape polyphenols and propolis mixture inhibits inflammatory mediator release from human leukocytes and reduces clinical scores in experimental arthritis

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

A J Farrell, David R. Blake, Richard Palmer et al. · Annals of the Rheumatic Diseases · 1992 · 718 citations · Full text

Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity

Paul P. Tak, Tom Smeets, Mohamed R. Daha et al. · Arthritis & Rheumatism · 1997 · 537 citations

Inhibitory Effects of Anthocyanins and Other Phenolic Compounds on Nitric Oxide Production in LPS/IFN-γ-Activated RAW 264.7 Macrophages

J. Wang, Giuseppe Mazza · Journal of Agricultural and Food Chemistry · 2002 · 264 citations

Antimicrobial activity, phenolic profile and role in the inflammation of propolis

João Carlos Silva, Sandra Rodrigues, Xesús Feás et al. · Food and Chemical Toxicology · 2012 · 247 citations

Inflammation, Anti-inflammatory, Biochemistry +10

Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: Structure–activity relationship and molecular mechanisms involved

De‐Xing Hou, Takashi Yanagita, Takuhiro Uto et al. · Biochemical Pharmacology · 2005 · 226 citations

Inflammation, Structure–activity Relationship, Cyclooxygenase-2 Expression +9