A CD40 Signalosome Anchored in Lipid Rafts Leads to Constitutive Activation of NF-κB and Autonomous Cell Growth in B Cell Lymphomas

Functional rafts in cell membranes

Kai Simons, Elina Ikonen · Nature · 1997 · 9.7K citations

Life Sciences, Biochemistry, Cell Biology +14

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

Life Sciences, Biochemistry, Molecular Biology +11

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

Yoshihide Tsujimoto, L R Finger, Jorge J. Yunis et al. · Science · 1984 · 1.8K citations

Life Sciences, Genetics, Oncology +17

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

Jeffrey Winston, Peter R. Strack, Peggy Beer‐Romero et al. · Genes & Development · 1999 · 946 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

Harikrishna Nakshatri, Poornima Bhat‐Nakshatri, Daniel Martı́n et al. · Molecular and Cellular Biology · 1997 · 818 citations · Full text

Medicine, Molecular Biology, Oncology +16