Concepedia

The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore

David G. Washburn, Dennis A. Holt, Jason W. Dodson, J. Jeffrey McAtee, Lamont R. Terrell, Linda S. Barton, Sharada Manns, Anna Waszkiewicz, Christina Pritchard, Dan Gillie,

Bioorganic & Medicinal Chemistry Letters · 2013 · 58 citations · 15 references

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References

15

Calcium - a life and death signal

Michael J. Berridge, Martin D. Bootman, Peter Lipp · Nature · 1998 · 2.1K citations

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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

Thomas Hofmann, Alexander G. Obukhov, Michael Schaefer et al. · Nature · 1999 · 1.5K citations

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Increased Vascular Smooth Muscle Contractility in <i>TRPC6</i><sup>−</sup><sup>/</sup><sup>−</sup> Mice

Alexander Dietrich, Michael Mederos y Schnitzler, Maik Gollasch et al. · Molecular and Cellular Biology · 2005 · 511 citations · Full text

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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Shigeki Kiyonaka, Kenta Kato, Motohiro Nishida et al. · Proceedings of the National Academy of Sciences · 2009 · 387 citations · Full text

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Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2

Christof Zitt, Eva C. Schwarz, Nicola Spaeth et al. · Journal of Biological Chemistry · 2004 · 291 citations · Full text

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