Concepedia

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

Peter Makhov, Konstantin Golovine, Ervin Teper, Alexander Kutikov, Reza Mehrazin, Anthony Corcoran, Alexei V. Tulin, Robert G. Uzzo, Vladimir Kolenko

British Journal of Cancer · 2014 · 122 citations · 38 references

DOIFull text

Open access

Abstract

Our data provide novel therapeutic opportunities to mediate cancer cellular death using PL. As such, PL may afford a novel paradigm for both prevention and treatment of malignancy.

References

38

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 6.9K citations · Full text

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology · 2011 · 6.8K citations · Full text

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

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mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Kathryn O’Reilly, F. Rojo, Qing‐Bai She et al. · Cancer Research · 2006 · 2.5K citations · Full text

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

Ravi K. Amaravadi, Duonan Yu, Julian J. Lum et al. · Journal of Clinical Investigation · 2007 · 1.1K citations · Full text