Therapeutic proteins — a pharmaceutical perspective

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

Donald R. Bertolini, Glenn E. Nedwin, Timothy S. Bringman et al. · Nature · 1986 · 1.4K citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +13

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

Abraham Abuchowski, T. van Es, Nicholas C. Palczuk et al. · Journal of Biological Chemistry · 1977 · 1.4K citations · Full text

Life Sciences, Biochemistry, Clinical Biochemistry +7

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

Peter P. Nawroth, D Stern · The Journal of Experimental Medicine · 1986 · 1.3K citations · Full text

Veterinary Medicine, Hematology, Immunology +17

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

Abraham Abuchowski, Judy McCoy, Nicholas C. Palczuk et al. · Journal of Biological Chemistry · 1977 · 1.3K citations · Full text

Life Sciences, Biochemistry, Immunology +14

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

Jean‐Michel Dayer, Bruce Beutler, Anthony Cerami · The Journal of Experimental Medicine · 1985 · 1.2K citations · Full text

Life Sciences, Cell Biology, Immunology +17