A unique and highly facile method for synthesising disulfide linked neoglycoconjugates: a new approach for remodelling of peptides and proteins

Abstract

An asymmetric disulfide linkage, formed by conjugation of a 5-nitropyridine-2-sulfenyl activated thioglycoside and a protein or pre-assembled peptide sequence, represents a good structural mimic of natural asparagine glycosylation.