Concepedia

The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas

Pablo Pérez‐Piñera, Tatiana Hernández, Olivia García‐Suárez, Antonino Germanà, Aurora Astudillo, José A. Vega

Molecular and Cellular Biochemistry · 2006 · 58 citations · 23 references

DOI

Concepts

References

23

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

, , +17

Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms

Ralf Erber, Andreas Thurnher, A. D. Katsen et al. · The FASEB Journal · 2003 · 603 citations

, , +17

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

Peter Tapley, Fabienne Lamballe, Mariano Barbacid · PubMed · 1992 · 501 citations

, , +16

Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75 ngfr , TrkA, TrkB, and TrkC) in the adult human peripheral nervous system and nonneural tissues

Masahiko Yamamoto, Gen Sobue, Kazutoshi Yamamoto et al. · Neurochemical Research · 1996 · 287 citations

, , +17

Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues.

E Shibayama, Hirotaka Koizumi · PubMed · 1996 · 271 citations

, , +16