Concepedia

Reaction of 2′‐Deoxyguanosine with Glyceraldehyde

Stefan Ochs, Theodor Severin

Liebigs Annalen der Chemie · 1994 · 30 citations · 9 references

DOI

Concepts

Abstract

Abstract Reaction of 2′‐deoxyguanosine with glyceraldehyde under physiological conditions leads to the formation of ammonium 2‐[9‐(2‐deoxy‐β‐ D ‐ribofuranosyl)‐6,9‐dihydro‐6‐oxo‐1 H ‐purin‐2‐ylamino]propionate ( 8 ). The same substance can be detected in 2′‐deoxyguanosine/glucose reaction mixtures as minor product. magnified image

References

9

New Aspects of the Maillard Reaction in Foods and in the Human Body

Franz Ledl, Erwin Schleicher · Angewandte Chemie International Edition in English · 1990 · 734 citations

, , +14

The maillard reaction in aging, diabetes and nutrition

Anna J. Furth · Trends in Biochemical Sciences · 1990 · 373 citations

, , +6

Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression.

Richard Bucala, Peter Model, Anthony Cerami · Proceedings of the National Academy of Sciences · 1984 · 210 citations · Full text

, , +15

Reaction of guanine with glyoxal, pyruvaldehyde, and kethoxal, and the structure of the acylguanines. Synthesis of N2-alkylguanines

Robert Shapiro, Bertram I. Cohen, S.-J. Shiuey et al. · Biochemistry · 1969 · 138 citations

, , +5

Synthesis and Antitumor Activity of 9-(Tetrahydro-2-furyl)purine Analogs of Biologically Important Deoxynucleosides<sup>1</sup>

William A. Bowles, F. H. Schneider, Leland R. Lewis et al. · Journal of Medicinal Chemistry · 1963 · 65 citations

, , +8