Concepedia

6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism-based inhibitors of human leukocyte elastase

John E. Kerrigan, Matthew C. Walters, Kerri J. Forrester, Jason B Crowder, Lisa J. Christopher

Bioorganic & Medicinal Chemistry Letters · 2000 · 14 citations · 14 references

DOI

Concepts

References

14

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

David A. Johnson, James Travis · Journal of Biological Chemistry · 1978 · 263 citations · Full text

, , +14

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

J. Wade Harper, Keiji Hemmi, James C. Powers · Biochemistry · 1985 · 229 citations

, , +9

Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin.

Scott B. Daniels, E Cooney, Michael J. Sofia et al. · Journal of Biological Chemistry · 1983 · 100 citations · Full text

, , +15

Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.

Fumitaka Ogushi, Richard C. Hubbard, Claus Vogelmeier et al. · Journal of Clinical Investigation · 1991 · 90 citations · Full text

, , +12

Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors

J. Wade Harper, James C. Powers · Biochemistry · 1985 · 80 citations

, , +9