Fumitaka Ogushi

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.

Fumitaka Ogushi, G A Fells, Richard C. Hubbard et al. · Journal of Clinical Investigation · 1987 · 216 citations · Full text

Life Sciences, Genetics, Immunology +9

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

Richard C. Hubbard, Fumitaka Ogushi, G A Fells et al. · Journal of Clinical Investigation · 1987 · 157 citations · Full text

Life Sciences, Immunology, Immunophysiology +10

Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene.

T. Nukiwa, Ken Satoh, Mark Brantly et al. · Journal of Biological Chemistry · 1986 · 127 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Chymase is a potent chemoattractant for human monocytes and neutrophils

Kenji Tani, Fumitaka Ogushi, Hiroshi Kido et al. · Journal of Leukocyte Biology · 2000 · 115 citations

Life Sciences, Biochemistry, Immunology +14

Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.

Fumitaka Ogushi, Richard C. Hubbard, Claus Vogelmeier et al. · Journal of Clinical Investigation · 1991 · 90 citations · Full text

Life Sciences, Biochemistry, Immunology +12