Effects of<i>CYP2D6</i>genotypes on age‐related change of flecainide metabolism: involvement of CYP1A2‐mediated metabolism

Abstract

The results suggest that patients with poor CYP2D6-mediated metabolism (het-EMs and IMs/PMs) showed age-related reduction in flecainide metabolism because metabolism was taken over by CYP1A2, whose activity decreases with age.