Prostacyclin is not a circulating hormone

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

Robert R. Gorman, S Bunting, O.V. Miller · Prostaglandins · 1977 · 655 citations

Medicine, Biochemistry, Pharmacology +10

Prostacyclin is a circulating hormone

Salvador Moncada, Ryszard Korbut, Stuart Bunting et al. · Nature · 1978 · 379 citations

Life Sciences, Endocrinology, Hormone Biochemistry +2

Generation of prostacyclin by lungs in vivo and its release into the arterial circulation

Ryszard J. Gryglewski, Ryszard Korbut, A. Ocetkiewicz · Nature · 1978 · 374 citations

Medicine, Pharmacology, Pharmacodynamics +5

Elevated Thromboxane Levels in the Rat during Endotoxic Shock

James A. Cook, W. C. Wise, Perry V. Halushka · Journal of Clinical Investigation · 1980 · 242 citations · Full text

Medicine, Immunology, Pharmacology +10