Concepedia

Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2

Jingbo Pi, Yushi Bai, Jeffrey M. Reece, Jason G. Williams, Dianxin Liu, Michael L. Freeman, William E. Fahl, David Shugar, Jie Liu, Wei Qu

Free Radical Biology and Medicine · 2007 · 210 citations · 30 references

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30

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

Petra Boukamp, R T Petrussevska, Dirk Breitkreutz et al. · The Journal of Cell Biology · 1988 · 4.2K citations · Full text

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

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Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Donna D. Zhang, Shih‐Ching Lo, Janet V. Cross et al. · Molecular and Cellular Biology · 2004 · 1.2K citations

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

Sara B. Cullinan, Donna Zhang, Mark Hannink et al. · Molecular and Cellular Biology · 2003 · 1.2K citations · Full text

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Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

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