Properties of a selective kappa agonist, U-50,488H

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

Charles Chavkin, Iain F. James, Avram Goldstein · Science · 1982 · 1.2K citations

Medicine, Medicinal Chemistry, Pharmacology +17

Bremazocine: A potent, long-acting opiate kappa-agonist

D. Römer, Heinz H. Büscher, Ronald C. Hill et al. · Life Sciences · 1980 · 314 citations

Medicine, Pharmacology, Behavioral Pharmacology +8

Chronic naloxone results in prolonged increases in opiate binding sites in brain

Robert A. Lahti, R. James Collins · European Journal of Pharmacology · 1978 · 170 citations

Medicine, Neuroscience, Pharmacology +15