An inhibitor of advanced glycation end product formation reducesN-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats

Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain

K Kawano, Tsukasa Hirashima, Seijiro Mori et al. · Diabetes · 1992 · 875 citations

Metabolic Syndrome, Metabolic Disorder, Physiology +8

N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

Thomas Kislinger, Caifeng Fu, Birgit Huber et al. · Journal of Biological Chemistry · 1999 · 860 citations · Full text

The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions

Min-Xin Fu, Jesús R. Requena, Alicia J. Jenkins et al. · Journal of Biological Chemistry · 1996 · 793 citations · Full text

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

Erwin Schleicher, Ernst Wagner · Journal of Clinical Investigation · 1997 · 708 citations · Full text

Lipid Peroxidation, Glycobiology, Oxidative Stress +20

<i>N</i> ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

Mahtab U. Ahmed, Elisabeth Brinkmann Frye, Thorsten P. Degenhardt et al. · Biochemical Journal · 1997 · 593 citations · Full text