Concepedia

CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis

Michael Mølhøj, Sandrine Crommer, Klaus Brischwein, Doris Rau, Mirnaalini Sriskandarajah, Patrick Hoffmann, Peter Kufer, Robert Hofmeister, Patrick A. Baeuerle

Molecular Immunology · 2006 · 108 citations · 29 references

DOI

Concepts

References

29

The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

Jane C. Stinchcombe, Giovanna Bossi, Sarah Booth et al. · Immunity · 2001 · 801 citations · Full text

, , +11

T cell killing does not require the formation of a stable mature immunological synapse

Marco A. Purbhoo, Darrell J. Irvine, Johannes B. Huppa et al. · Nature Immunology · 2004 · 578 citations

, , +12

A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes

Anja Löffler, Peter Kufer, Ralf Lutterbüse et al. · Blood · 2000 · 445 citations

, , +17

Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells

Sonja Offner, Robert Hofmeister, Andrea Romaniuk et al. · Molecular Immunology · 2005 · 365 citations

, , +16

Extremely potent, rapid and costimulation‐independent cytotoxic T‐cell response against lymphoma cells catalyzed by a single‐chain bispecific antibody

Torsten Dreier, Grit Lorenczewski, Christian Brandl et al. · International Journal of Cancer · 2002 · 354 citations · Full text

, , +17