Johannes B. Huppa

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

Björn F. Lillemeier, Manuel Mörtelmaier, Martin B. Forstner et al. · Nature Immunology · 2009 · 630 citations

Protein Function, Signal Transduction, Molecular Biology +8

T cell killing does not require the formation of a stable mature immunological synapse

Marco A. Purbhoo, Darrell J. Irvine, Johannes B. Huppa et al. · Nature Immunology · 2004 · 569 citations

Immunological Memory, Autoimmune Disease, Adaptive Immune System +12

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

Johannes B. Huppa, Markus Axmann, Manuel Mörtelmaier et al. · Nature · 2010 · 501 citations

Biochemistry, Tcr–peptide–mhc Interactions, Natural Sciences +4

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

Johannes B. Huppa, Michael Gleimer, Cenk Sumen et al. · Nature Immunology · 2003 · 399 citations

Signal Transduction, Synaptic Transmission, T-regulatory Cell +11

Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity

Michelle Krogsgaard, Qijing Li, Cenk Sumen et al. · Nature · 2005 · 342 citations

Immunology, Antigen Processing, T Cell Immunity +6