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Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases

Yusuke Oka, Tetsuya Yabuuchi, Takahiro Oi, Shoichi Kuroda, Yasuyuki Fujii, Hidenori Ohtake, Tomoyuki Inoue, Shunichi Wakahara, Kayo Kimura, Kiyoko Fujita,

Bioorganic & Medicinal Chemistry · 2013 · 21 citations · 9 references

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References

9

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

Emilio Hirsch, Vladimir L. Katanaev, Cecília Garlanda et al. · Science · 2000 · 1.2K citations

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Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

Takehiko Sasaki, Junko Irie-Sasaki, Russell G. Jones et al. · Science · 2000 · 1K citations

, , +17

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

Zhong Li, Huiping Jiang, Wei Xie et al. · Science · 2000 · 816 citations

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Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 751 citations

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Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

Muriel Laffargue, Ronan Calvez, Peter M. Finan et al. · Immunity · 2002 · 288 citations · Full text

, , +16