Association of CYP1B1 with hypersensitivity induced by Taxane therapy in breast cancer patients

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 880 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

4-Hydroxylation of estrogens as marker of human mammary tumors.

Joachim G. Liehr, Mary Jo Ricci · Proceedings of the National Academy of Sciences · 1996 · 415 citations

Life Sciences, Biochemistry, Oncology +17

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations

Medicine, Biochemistry, Pharmacology +17

Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity.

Imad H Hanna, Sheila Dawling, Nady Roodi et al. · PubMed · 2000 · 313 citations

Medicine, Biochemistry, Genetics +14

Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.

James W. Harris, Atiqur Rahman, Bok-Ryang Kim et al. · PubMed · 1994 · 286 citations

Medicine, Biochemistry, Pharmacology +17