Concepedia

Chemical and Biochemical Studies with Dithioate DNA

Marvin H. Caruthers, Graham Beaton, Lendell L. Cummins, Douglas J. Dellinger, D. Graff, Yunxi Ma, William S. Marshall, Henri Sasmor, Paula Shankland, John Van Wu,

Nucleosides and Nucleotides · 1991 · 25 citations · 16 references

DOI

Concepts

Abstract

Abstract Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in Hela cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.

References

16

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

David J. Galas, Albert Schmitz · Nucleic Acids Research · 1978 · 2.1K citations · Full text

, , +11

Gene Synthesis Machines: DNA Chemistry and Its Uses

Marvin H. Caruthers · Science · 1985 · 791 citations

, , +15

Physicochemical properties of phospborothioate oligodeoxynucleotides

C.A. Stein, Kazuo Shinozuka, Jack S. Cohen · Nucleic Acids Research · 1988 · 584 citations · Full text

, , +13

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

Douglas L. Black, Benoı̂t Chabot, Joan A. Steitz · Cell · 1985 · 573 citations

, , +14

Nucleosides and Nucleotides

Kazunobu Miura, Masatoshi SHIGA, Tohru Ueda · The Journal of Biochemistry · 1973 · 487 citations

, , +15