Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

Life Sciences, Neuroscience, Pharmacology +14

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

William J. Nicklas, I Vyas, Richard E. Heikkila · Life Sciences · 1985 · 1.3K citations

Life Sciences, Biochemistry, Neuroscience +14

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony J. Trevor, Neal Castagnoli · Biochemical and Biophysical Research Communications · 1984 · 1.1K citations

Life Sciences, Neuroscience, Pharmacology +14

AETIOLOGY OF PARKINSON'S DISEASE

DonaldB. Calne, J. William Langston · The Lancet · 1983 · 466 citations

Medicine, Neurology, Neuroscience +12

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

J. William Langston, Ian Irwin, Elizabeth B. Langston et al. · Neuroscience Letters · 1984 · 432 citations

Pharmacy, Pharmacology, Toxicology +15